We are thrilled to welcome you to the 18th International Conference on Tissue Engineering and Regenerative Medicine, held on April 23-24, 2025, in Paris, France. This conference serves as a premier platform for experts, researchers, clinicians, and professionals to explore the latest advancements in tissue engineering, stem cell therapy, regenerative medicine, and biomaterials.  

 

Throughout the event, you will have the chance to engage in stimulating discussions, attend cutting-edge presentations, and share ideas that drive innovation in this dynamic field. Our goal is to foster collaboration and inspire new partnerships to tackle the challenges of tissue regeneration and improve patient outcomes.  

 

We hope this conference provides you with valuable insights, encourages knowledge exchange, and sparks meaningful connections. We are excited to have you join us in Paris for an unforgettable experience!  

Fundamentals of Tissue Engineering

Tissue engineering is a multidisciplinary field that combines principles of biology, materials science, and engineering to create functional tissues for repairing or replacing damaged organs. The process involves using living cells, biocompatible scaffolds, and bioactive molecules to support cell growth and tissue development. Scaffolds mimic the extracellular matrix, providing structural support and guiding cell behaviour for regeneration. Critical components include understanding cellular interactions, material properties, and biochemical signalling. Advances in stem cells, biomaterials, and 3D bio printing have expanded its applications, from skin grafts to organ reconstruction, offering innovative solutions for regenerative medicine and reducing the dependence on donor transplants.

Biomaterials for Tissue Engineering

Biomaterials are essential in tissue engineering, serving as scaffolds to support cell attachment, proliferation, and tissue regeneration. These materials can be natural, synthetic, or hybrid, each offering unique advantages. Natural biomaterials, such as collagen, fibrin, and alginate, closely mimic the extracellular matrix, promoting biocompatibility and bioactivity. Synthetic biomaterials, including polylactic acid (PLA), polyglycolic acid (PGA), and polyethylene glycol (PEG), provide tunable properties like strength, degradation rate, and reproducibility. Advances in composite biomaterials combine the strengths of both types. Ideal biomaterials are biocompatible, biodegradable, and mechanically suitable, facilitating cell signaling, vascularization, and tissue integration for effective regenerative therapies.

3D Bio printing and Additive Manufacturing

3D bioprinting and additive manufacturing are transformative technologies in tissue engineering, enabling the creation of complex, functional biological structures layer by layer.3D bioprinting uses bioinks—comprising living cells, biomaterials, and growth factors—to fabricate tissue constructs that mimic the architecture of native tissues. Techniques like extrusion, inkjet, and laser-assisted bioprinting allow precise deposition of materials and cells, facilitating applications such as organ models, skin grafts, and vascularized tissues.

Additive manufacturing extends beyond bioprinting, encompassing methods like stereolithography and selective laser sintering to produce scaffolds with tailored mechanical and biochemical properties, offering unprecedented control over design and customization for patient-specific regenerative therapies.

Stem Cell Research and Applications

Stem cell research explores the properties of stem cells—undifferentiated cells capable of self-renewal and differentiation into specialized cell types. This field holds immense promise for regenerative medicine, disease modeling, and drug discovery. Embryonic stem cells (ESCs)  and  induced pluripotent stem cells (iPSCs) offer pluripotency, enabling them to differentiate into any cell type. Adult stem cells, like mesenchymal stem cells (MSCs) and hematopoietic stem cells (HSCs), are multipotent and are used in therapies such as bone marrow transplants. 

Applications include treating neurodegenerative diseases, diabetes, heart failure, and spinal injuries. Stem cells are also vital for creating organoids, enhancing personalized medicine, and revolutionizing tissue engineering approaches.

Organs-on-Chips and Micro physiological Systems

Organs-on-chips (OoCs) and microphysiological systems (MPS) are innovative bioengineering platforms that simulate the structure and function of human organs on microfluidic devices. These systems integrate living cells, biomaterials, and microchannels to recreate the cellular architecture, mechanical forces, and biochemical environments of specific tissues or organs.

OoCs enable the study of organ-specific responses to drugs, diseases, and toxins in a controlled, human-relevant context, reducing reliance on animal testing. MPS expands this concept by connecting multiple organ chips, mimicking systemic interactions like metabolism and drug distribution. Applications include precision medicine, disease modeling, drug development, and advancing personalized therapeutic strategies.

Tissue Repair and Regeneration

Tissue repair and regeneration encompass the body’s mechanisms to heal and restore damaged tissues to their original structure and function. Tissue repair  typically involves processes like inflammation, cell proliferation, and remodeling, often resulting in scar formation to replace lost or damaged tissue. In contrast,  tissue regeneration aims to fully restore the original tissue without scarring, requiring precise cellular coordination and signaling. Advances in tissue engineering enhance these natural processes by utilizing biomaterials, stem cells, and bioactive molecules  to create environments that promote effective healing. Techniques such as scaffold implantation, growth factor delivery, and gene therapy support the regeneration of complex tissues like bone, cartilage, and neural networks.  diseases, and improving patient outcomes by restoring functionality and aesthetics .

Clinical Applications of Regenerative Medicine

Regenerative medicine applies innovative techniques to restore damaged tissues and organs, offering transformative solutions in healthcare. Stem cell therapies are widely used for treating neurodegenerative disorders like Parkinson's disease, repairing cartilage in orthopedics, and managing blood disorders through bone marrow transplants. Tissue engineering has enabled the creation of bioengineered skin for burns and chronic wounds and advances in organ reconstruction. Moreover, gene therapy is enhancing precision medicine by correcting genetic disorders. In cardiology, regenerative approaches aim to repair heart tissue post-myocardial infarction, while in neurology, they aid in stroke and spinal cord injury recovery. These breakthroughs are revolutionizing treatments, reducing reliance on organ transplants, and improving patients' quality of life, marking a new era in modern medicine.

Immunological Considerations in Tissue Engineering

Immunological considerations are critical in tissue engineering to ensure graft acceptance and functional integration. Biocompatibility of biomaterials is paramount, as immune reactions like inflammation or fibrosis can compromise outcomes. Using autologous cells minimizes rejection risks but limits scalability, while allogeneic cells pose challenges due to immune incompatibility. Immune modulation strategies, such as incorporating anti-inflammatory biomaterials or localized immunosuppressants, are crucial for enhancing acceptance. Additionally, understanding the roles of innate and adaptive immunity helps in designing constructs that avoid chronic rejection. Advances in bioengineering, such as decellularized scaffolds and immune-evasive designs, aim to mitigate immune responses, paving the way for more reliable and durable tissue-engineered solutions in regenerative medicine.

Regenerative Approaches in Cardiovascular Medicine

Regenerative medicine revolutionizes cardiovascular care by repairing damaged heart tissue and blood vessels. Stem cell therapy regenerates myocardium post-infarction, enhancing heart function. Tissue engineering produces bioengineered cardiac patches, heart valves, and vascular grafts for structural repair. Gene therapy stimulates angiogenesis and promotes cell survival, aiding in heart recovery. Exosome-based therapies, derived from cell vesicles, help reduce inflammation and enhance tissue repair. Additionally, bioactive materials like hydrogels and scaffolds deliver therapeutic cells and growth factors effectively to damaged areas. These innovative approaches offer transformative solutions for managing heart diseases, reducing reliance on traditional interventions, and improving patient outcomes in cardiovascular medicine.

Regulatory and Ethical Considerations

Regenerative medicine's rapid advancements require robust regulatory and ethical frameworks to ensure safety, efficacy, and fairness. Clinical trials and approvals must adhere to stringent standards, such as FDA or EMA regulations, to validate therapies and ensure patient safety. Long-term monitoring is critical to identify potential risks, such as tumorigenicity in stem cell-based treatments. Ethical sourcing is particularly significant for embryonic stem cells, requiring strict guidelines for informed consent and responsible procurement. Addressing disparities in access is vital to prevent inequities in benefiting from these innovations. Transparent commercialization is also essential to counter the misuse of unproven therapies and ensure affordability. Furthermore, ensuring patient autonomy and understanding through clear communication fosters trust. These measures collectively support the responsible development and integration of regenerative medicine into clinical practice, balancing innovation with societal and ethical responsibility.
 
Personalized Medicine and Tissue Engineering

Regenerative medicine’s rapid progress requires stringent regulatory and ethical frameworks to ensure safety, efficacy, and fairness. Clinical trials must meet rigorous standards set by bodies like the FDA or EMA to validate therapies before approval. Ensuring patient safety, particularly for stem cell-based interventions, is critical to prevent long-term adverse effects. Ethical sourcing of stem cells, especially embryonic ones, demands adherence to strict guidelines, informed consent, and transparency. Addressing healthcare equity is vital to ensure that cutting-edge treatments are accessible to all, not just privileged populations. The commercialization of regenerative therapies must avoid exploitation by prohibiting misleading claims about unproven treatments. Furthermore, continuous dialogue between scientists, ethicists, and policymakers is essential to navigate evolving challenges responsibly, fostering trust and advancing regenerative medicine for the benefit of society.

Cancer Tissue Engineering and Tumour Models

Regulatory and ethical considerations in regenerative medicine are essential to ensure the responsible development and application of new therapies. Regulatory oversight, by agencies like the FDA and EMA, ensures rigorous clinical testing for safety and efficacy before approval. Patient safety remains a priority, particularly in stem cell-based therapies and the use of biomaterials, to prevent long-term adverse effects. Ethical sourcing of stem cells, especially embryonic stem cells, raises concerns about informed consent and respect for donor rights. Equity and access are vital, as emerging therapies can exacerbate healthcare inequalities, with some populations lacking access to advanced treatments. Furthermore, commercialization must be handled ethically, ensuring that therapies are marketed based on evidence and not prematurely hyped. Balancing innovation with ethical guidelines is crucial to ensure that regenerative medicine benefits all patients safely and fairly.

Advances in Artificial Organs and Implants

Advances in artificial organs and implants have revolutionized treatment options for patients with organ failure or severe tissue damage. Artificial organs, such as bioengineered kidneys, livers, and hearts, are designed to replicate the functions of their biological counterparts, offering solutions for patients awaiting transplants. 3D printing has played a crucial role in creating customized implants, including prosthetic limbs, joints, and scaffolds for tissue regeneration. Biocompatible materials like titanium and advanced polymers have improved the longevity and functionality of implants, reducing the risk of rejection. Moreover, smart implants, equipped with sensors and actuators, allow real-time monitoring and regulation of biological functions, such as drug delivery or heart rate management. These breakthroughs are not only improving the quality of life but also addressing the global organ shortage, offering promising alternatives to traditional transplantation and enhancing patient outcomes.

Emerging Trends in Tissue Engineering

Emerging trends in tissue engineering are transforming regenerative medicine, driven by technological advancements and innovative approaches. 3D bioprinting is gaining prominence, enabling the creation of complex, customized tissue structures by printing cells and biomaterials in precise patterns. Organ-on-a-chip technology is improving drug testing and disease modeling by mimicking human organ systems in miniature, enhancing the development of functional tissues. Decellularized scaffolds are being used more frequently, offering a natural framework for tissue regeneration by removing cellular components from donor tissues while retaining the extracellular matrix. Stem cell therapies continue to evolve, with advances in induced pluripotent stem cells (iPSCs) offering greater potential for creating patient-specific tissues. Additionally, bioactive materials, such as hydrogels and nanoparticles, are enhancing cell growth and improving tissue integration. These trends promise to accelerate tissue engineering applications, improving patient outcomes and expanding treatment options.

Attending the 18th International Conference on Tissue Engineering and Regenerative Medicine, scheduled for April 23-24, 2025, in Paris, France, is a must for anyone involved in tissue engineering, regenerative medicine, and related fields. This conference offers an exceptional platform to stay updated on the latest research, innovations, and breakthroughs in tissue regeneration, stem cell therapy, and biomaterials. Through thought-provoking presentations, interactive sessions, and numerous networking opportunities, attendees can broaden their knowledge, exchange ideas, and establish valuable connections with experts and peers in the field.

 

Target Audience:
 

- Tissue Engineers

- Stem Cell Researchers

- Regenerative Medicine Professionals

- Biotechnologists

- Biomedical Engineers

- Clinical Researchers

- Healthcare Providers

- Biomaterials Scientists

- Surgeons and Medical Professionals

- Academics and Educators

- Students and Trainees

- Industry Leaders and Entrepreneurs

- Policy Makers and Regulators

- Companies in Pharmaceuticals, Biotechnology, and Medical Devices

 

This conference is ideal for those looking to expand their knowledge, collaborate with experts, and explore innovative solutions in regenerative medicine.

Participation Benefits :

• Benefit from attending keynote presentations by esteemed researchers.
• Gain access to all sessions and networking opportunities.
• Receive global recognition for your research and profile.
• Get the opportunity to publish abstracts in international journals with unique DOIs.
• Obtain discounts for publishing articles in open-access journals.
• Receive handbooks and conference kits to enhance your experience.
• Network with prominent figures from around the globe.
• Learn and expand your knowledge from top professionals in the field.
• Receive certified participation for your abstracts.
• Establish global connections for your research ideas and professional growth.

Participation categories:

• Keynote Speaker: Share your insights as a prominent figure in the field in a 45-50 minute presentation.
• Speaker (Oral Presentation): Showcase your individual research or expertise in a 25-30 minute presentation.
• Speaker (Workshop): Provide interactive learning experiences in a 45-50 minute workshop.
• Speaker (Special Session): Contribute to a special session for 45-50 minutes alongside fellow experts.
• Speaker (Symposium): Collaborate with multiple presenters in a symposium lasting more than 45 minutes.
• Delegate (Registration Only): Access all sessions and benefits upon registration.
• Poster Presenter: Showcase your research through poster presentations and enjoy delegate benefits.
• Remote Attendance: Participate via video or e-poster presentation.
• Exhibitor: Display your company products through booked booths of varying sizes.
• Media Partner, Sponsor, and Collaborator: Collaborate with the event, offering support and visibili